Thymosin Alpha-1 (TA-1)
Research Material
- AreaLongevity
- CAS62304-98-7
- Purity≥99%
$59.95
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Epithalon (also written Epitalon; sequence Ala-Glu-Asp-Gly, abbreviated AEDG) is a synthetic tetrapeptide developed as the short-chain analogue of the pineal polypeptide preparation Epithalamin. First synthesized in the laboratory of Vladimir Khavinson, it has become a widely referenced model compound in gerontological and telomere-biology research. With a molecular formula of C14H22N4O9 and a molecular weight of 390.35 g/mol, Epithalon is one of the smallest peptides studied in the context of cellular senescence and pineal regulation.
Research literature on Epithalon centers on its reported influence over telomerase activity in cultured somatic cells, its interactions with chromatin and specific gene-promoter regions, and its proposed role in circadian and neuroendocrine signaling associated with the pineal gland. These investigations position AEDG as a peptide bioregulator model, though the precise molecular targets and mechanisms remain an active subject of study. This material is supplied strictly for laboratory research use.
Ala-Glu-Asp-Gly
Research use only — not for human or animal consumption. Per-batch documentation is provided with the material.
Published research on Epithalon has reported activation of telomerase and elongation of telomeres in cultured human fibroblast and somatic cell populations, alongside observations of altered gene-promoter binding and modulation of melatonin-associated rhythms in animal models. The peptide is frequently framed within the concept of "peptide bioregulation," in which short peptides are proposed to influence tissue-specific gene expression.
These reports are drawn largely from in vitro systems and rodent studies; mechanisms remain incompletely characterized and results are not established for humans. Epithalon is offered solely as a research reagent.
Epithalon was designed as the tetrapeptide analogue of Epithalamin, a peptide extract of the pineal gland studied in the Soviet Union and Russia beginning in the 1980s. Its synthesis and much of the foundational research are attributed to Russian gerontologist Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology, who advanced the broader "peptide bioregulator" framework.
View compound profile on NIH PubChem →
Cited literature refers to laboratory and preclinical research. Epithalon is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.
